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Symptoms of Toxicities
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Table 1 gives the symptoms of vitamin and mineral toxicities. Toxicities occur at lower intake levels in infants, children, and pregnant and lactating women. If a woman takes excessive amounts of many vitamins and minerals while pregnant her child can be affected.

Table 1 also gives the lowest doses at which toxicities have been reported in reliable scientific publications. The literature contains many case studies where nutrient overdoses are presumed to affect health adversely. The nutrient amounts and time that people with toxicity problems took the nutrients are frequently not given so it is difficult to determine minimum toxicity levels. Size, age, sex, genetic background, as well as general health and previous nutritional status of individuals also affects responses to over consumption of vitamins and minerals.

Complications

Some nutrients have specific pharmacologic effects at high dosages. Pharmacologic doses sometimes, but not always, reduce symptoms of certain diseases and metabolic conditions, and complicate the diagnosis of certain diseases. They also influence treatment of some diseases and metabolic conditions. Medications may interact with vitamins and minerals and influence medicine effectiveness.

Adaptation

Individuals can adapt to taking large amounts of a vitamin or a mineral. And, if they stop taking high levels of nutrient supplements and start consuming normal levels, they can develop nutritional deficiency diseases (for example, scurvy). If one desires to stop taking large doses of a vitamin or mineral, the intake should be gradually decreased.

Legal Regulations

Some supplements have been contaminated and some have failed to meet advertised claims. Because supplements are legally considered to be foods not drugs, the Food and Drug Administration has few regulations concerning them. Regulations are being proposed on the marketing of high dosage supplements.

Selected References

File NF97 under FOODS AND NUTRITION
C-1g, Nutrition-Nutritive Value of Foods
Issued October 1992

Issued in furtherance of Cooperative Extension work, Acts of May 8 and June 30, 1914, in cooperation with the U.S. Department of Agriculture. Kenneth R. Bolen, Director of Cooperative Extension, University of Nebraska, Institute of Agriculture and Natural Resources.

University of Nebraska Cooperative Extension educational programs abide with the non-discrimination policies of the University of Nebraska-Lincoln and the United States Department of Agriculture.

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